Suspension Presentation

Each liquid contains:
Sucralflate 1000 mg

Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers, gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a cytoprotective agent, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances.

Uses

• Gastric Ulcer
• Gastritis
• Gastro-esophageal Reflux Disease (GERD)
• Healing
• Mucositis
• Peptic Ulcer
• Stress Ulcers
• Active Duodenal ulcer
• Dyspepsia

Mechanism of action

This drug aids in the healing of duodenal ulcers, relieving painful inflammation by creating a protective mechanical barrier between the lining or skin of the gastrointestinal tract and damaging substances. Sucralfate forms a complex that binds to protein-rich exudate found on the surface of ulcers. It binds to albumin and fibrinogen, preventing blood clot lysis by stomach acid (hydrochloric acid). Sucralfate increases the tissue levels of fibroblast growth factors and epidermal growth factors, leading to an increase in prostaglandins at the gastrointestinal tract lining, which promote the healing of gastrointestinal ulcers. In addition, sucralfate acts to increase levels of growth factors locally, and also causes an increase in prostaglandins which are important in the healing of the mucosa (lining) of the gastrointestinal tract.

Side Effects

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage however dry mouth, feeling of fullness, loss of appetite and nausea can occur in some patients.

Interaction

• The therapeutic efficacy of warfarin can be decreased when used in combination with Sucralfate.
• Sucralfate may decrease the excretion rate of Abacavir which could result in a higher serum level.

Precaution

• Not to be used in pregnancy and breast feeding until prescribed by your physician
• Do not take antacids within 30 minutes of sucralfate dose.

Contraindication

• End-stage renal disease
• Uncontrolled diabetes mellitus with hyperglycemia
• Impaired swallowing/gag reflex